Systems-level effects of allosteric perturbations to a model molecular switch – Nature


Nature, Published on-line: 13 October 2021; doi:10.1038/s41586-021-03982-6

Interface mutations within the GTPase switch protein Gsp1 (the yeast homologue of human RAN) allosterically have an effect on the kinetics of the switch cycle, revealing a methods-stage mechanism of multi-specificity.

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